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Recombinant Human/Mouse/Rat Activin A Protein

(338-AC-010)



概述
货号 338-AC-010
别名 INHBA
反应种属 Human/Mouse/Rat
形式 Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
性能
供应商 R&D Systems
Entrez Gene IDs 3624 (Human); 16323 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Activin A programs the differentiation of human TFH cells
Nat Immunol, 2016;17(8):976-84.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Growth hormone is permissive for neoplastic colon growth
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
Stem Cell Res Ther, 2016;7(1):115.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-Versus-Host Disease in Mice
Stem Cells Transl Med, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells
PLoS ONE, 2016;11(7):e0159246.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation
Nat Commun, 2016;7(0):12603.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.
Authors: Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, Wang C
PLoS ONE, 2015;10(6):e0129643.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells.
Authors: Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, Morrisey E
PLoS ONE, 2015;10(8):e0134995.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
Authors: Gerbin K, Yang X, Murry C, Coulombe K
PLoS ONE, 2015;10(7):e0131446.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.
Authors: Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky T, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy A, Yancopoulos G, Gromada J, Stitt T
Skelet Muscle, 2015;5(0):34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human primordial germ cell commitment in vitro associates with a unique PRDM14 expression profile.
Authors: Sugawa F, Arauzo-Bravo M, Yoon J, Kim K, Aramaki S, Wu G, Stehling M, Psathaki O, Hubner K, Scholer H
EMBO J, 2015;34(8):1009-24.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
Nat Protoc, 2015;10(3):413-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease.
Authors: Stayte S, Rentsch P, Li K, Vissel B
PLoS ONE, 2015;10(4):e0124325.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Generation of articular chondrocytes from human pluripotent stem cells.
Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
Nat Biotechnol, 2015;33(6):638-45.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin receptor signaling regulates cocaine-primed behavioral and morphological plasticity.
Authors: Gancarz A, Wang Z, Schroeder G, Damez-Werno D, Braunscheidel K, Mueller L, Humby M, Caccamise A, Martin J, Dietz K, Neve R, Dietz D
Nat Neurosci, 2015;18(7):959-61.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Forced expression of Nanog or Esrrb preserves the ESC status in the absence of nucleostemin expression.
Authors: Katano M, Ema M, Nakachi Y, Mizuno Y, Hirasaki M, Suzuki A, Ueda A, Nishimoto M, Takahashi S, Okazaki Y, Okuda A
Stem Cells, 2015;33(4):1089-101.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo.
Authors: Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y
J Cell Sci, 2015;128(5):1011-22.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
Authors: Wilson C, Ottewell P, Coleman R, Holen I
BMC Cancer, 2015;15(0):55.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
Authors: Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S
PLoS ONE, 2015;10(8):e0136350.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
Stem Cells, 2015;33(3):742-50.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.
Authors: Kim M, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J
PLoS ONE, 2015;10(2):e0118670.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
Authors: Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
Development, 2015;142(8):1528-41.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Increased culture density is linked to decelerated proliferation, prolonged G1 phase, and enhanced propensity for differentiation of self-renewing human pluripotent stem cells.
Authors: Wu J, Fan Y, Tzanakakis E
Stem Cells Dev, 2015;24(7):892-903.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor.
Authors: Zhu G, Fei T, Li Z, Yan X, Chen Y
J Biol Chem, 2015;290(36):22019-29.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
DNA methylation directs functional maturation of pancreatic beta cells.
Authors: Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A
J Clin Invest, 2015;125(7):2851-60.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Low miR-143/miR-145 Cluster Levels Induce Activin A Overexpression in Oral Squamous Cell Carcinomas, Which Contributes to Poor Prognosis.
Authors: Bufalino A, Cervigne N, de Oliveira C, Fonseca F, Rodrigues P, Macedo C, Sobral L, Miguel M, Lopes M, Paes Leme A, Lambert D, Salo T, Kowalski L, Graner E, Coletta R
PLoS ONE, 2015;10(8):e0136599.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Reprogramming of HUVECs into induced pluripotent stem cells (HiPSCs), generation and characterization of HiPSC-derived neurons and astrocytes.
Authors: Haile, Yohannes, Nakhaei-Nejad, Maryam, Boakye, Paul A, Baker, Glen, Smith, Peter A, Murray, Allan G, Giuliani, Fabrizio, Jahroudi, Nadia
PLoS ONE, 2015;10(3):e0119617.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Alternative Routes to Induce Naive Pluripotency in Human Embryonic Stem Cells.
Authors: Duggal G, Warrier S, Ghimire S, Broekaert D, Van der Jeught M, Lierman S, Deroo T, Peelman L, Van Soom A, Cornelissen R, Menten B, Mestdagh P, Vandesompele J, Roost M, Slieker R, Heijmans B, Deforce D, De Sutter P, de Sousa Lopes S, Heindryckx B
Stem Cells, 2015;33(9):2686-98.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The Inhibitory Core of the Myostatin Prodomain: Its Interaction with Both Type I and II Membrane Receptors, and Potential to Treat Muscle Atrophy.
Authors: Ohsawa Y, Takayama K, Nishimatsu S, Okada T, Fujino M, Fukai Y, Murakami T, Hagiwara H, Itoh F, Tsuchida K, Hayashi Y, Sunada Y
PLoS ONE, 2015;10(7):e0133713.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A.
Authors: Merfeld-Clauss S, Lupov I, Lu H, March K, Traktuev D
Stem Cells, 2015;33(10):3039-51.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure.
Authors: Calderon-Gierszal E, Prins G
PLoS ONE, 2015;10(7):e0133238.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor beta (TGFbeta)-mediated Germ Layer Induction in Xenopus Embryos.
Authors: Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen Y, Zhang M, Tao Q, Wu W
J Biol Chem, 2015;290(28):17239-49.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
Authors: Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R
Cell Stem Cell, 2014;14(1):53-67.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods.
Authors: Araoka, Toshikaz, Mae, Shin-ich, Kurose, Yuko, Uesugi, Motonari, Ohta, Akira, Yamanaka, Shinya, Osafune, Kenji
PLoS ONE, 2014;9(1):e84881.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.
Authors: Watanabe, Hitoshi, Takayama, Kazuo, Inamura, Mitsuru, Tachibana, Masashi, Mimura, Natsumi, Katayama, Kazufumi, Tashiro, Katsuhis, Nagamoto, Yasuhito, Sakurai, Fuminori, Kawabata, Kenji, Furue, Miho Kus, Mizuguchi, Hiroyuki
PLoS ONE, 2014;9(3):e90791.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
PLoS Biol, 2014;12(8):e1001937.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche.
Authors: Jorgensen A, Young J, Nielsen J, Joensen U, Toft B, Rajpert-De Meyts E, Loveland K
Br J Cancer, 2014;110(10):2604-14.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
An activin receptor IIA ligand trap promotes erythropoiesis resulting in a rapid induction of red blood cells and haemoglobin.
Authors: Carrancio S, Markovics J, Wong P, Leisten J, Castiglioni P, Groza M, Raymon H, Heise C, Daniel T, Chopra R, Sung V
Br J Haematol, 2014;165(6):870-82.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A single-cell and feeder-free culture system for monkey embryonic stem cells.
Authors: Ono T, Suzuki Y, Kato Y, Fujita R, Araki T, Yamashita T, Kato H, Torii R, Sato N
PLoS ONE, 2014;9(2):e88346.
Species: Primate - Cynomolgus Monkey
Sample Type: Whole Cells
Application: Bioassay
Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant.
Authors: Takebe, Takanori, Zhang, Ran-Ran, Koike, Hiroyuki, Kimura, Masaki, Yoshizawa, Emi, Enomura, Masahiro, Koike, Naoto, Sekine, Keisuke, Taniguchi, Hideki
Nat Protoc, 2014;9(2):396-409.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes.
Authors: Hua X, Wang Y, Tang Y, Yu S, Jin S, Meng X, Li H, Liu F, Sun Q, Wang H, Li J
PLoS ONE, 2014;9(7):e102198.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enabling autologous human liver regeneration with differentiated adipocyte stem cells.
Authors: Xu, Dan, Nishimura, Toshihik, Zheng, Ming, Wu, Manhong, Su, Hua, Sato, Noboru, Lee, Gordon, Michie, Sara, Glenn, Jeffrey, Peltz, Gary
Cell Transplant, 2014;23(12):1573-84.
Species: Human
Sample Type: whole cells
Application: Bioassay
Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
Authors: Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz R, Barahona M, Schneider M
Stem Cells, 2014;32(6):1515-26.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.
Authors: Dambrot C, Braam S, Tertoolen L, Birket M, Atsma D, Mummery C
J Cell Mol Med, 2014;18(8):1509-18.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
Authors: Wile B, Ban K, Yoon Y, Bao G
Nat Protoc, 2014;9(10):2411-24.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo.
Authors: Luo J, Weaver M, Cao B, Dennis J, Van Biber B, Laflamme M, Allen M
Stem Cells Transl Med, 2014;3(6):734-44.
Species: Human
Sample Type: Whole Cell
Application: Bioassay
A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium.
Authors: Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, Maminishkis A, Marugan J, Sharma R, Shure M, Temple S, Miller S, Bharti K
Stem Cells Transl Med, 2014;3(8):911-22.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
Elife, 2014;3(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Ethanol negatively regulates hepatic differentiation of hESC by inhibition of the MAPK/ERK signaling pathway in vitro.
Authors: Gao W, Zhou P, Ma X, Tschudy-Seney B, Chen J, Magner N, Revzin A, Nolta J, Zern M, Duan Y
PLoS ONE, 2014;9(11):e112698.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
Authors: Chong J, Yang X, Don C, Minami E, Liu Y, Weyers J, Mahoney W, Van Biber B, Cook S, Palpant N, Gantz J, Fugate J, Muskheli V, Gough G, Vogel K, Astley C, Hotchkiss C, Baldessari A, Pabon L, Reinecke H, Gill E, Nelson V, Kiem H, Laflamme M, Murry C
Nature, 2014;510(7504):273-7.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Enzyme-free passage of human pluripotent stem cells by controlling divalent cations.
Authors: Ohnuma, Kiyoshi, Fujiki, Ayaka, Yanagihara, Kana, Tachikawa, Saoko, Hayashi, Yohei, Ito, Yuzuru, Onuma, Yasuko, Chan, Techuan, Michiue, Tatsuo, Furue, Miho K, Asashima, Makoto
Sci Rep, 2014;4(0):4646.
Species: Human
Sample Type: whole cells
Application: Bioassay
Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification.
Authors: Hoffman J, Wu C, Merrill B
Development, 2013;140(8):1665-75.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells.
Authors: White M, Rufaihah A, Liu L, Ghebremariam Y, Ivey K, Cooke J, Srivastava D
Stem Cells, 2013;31(1):92-103.
Species: Human
Sample Type: whole cells
Application: Bioassay
Production of hepatocyte-like cells from human pluripotent stem cells.
Authors: Hannan, Nicholas, Segeritz, Charis-P, Touboul, Thomas, Vallier, Ludovic
Nat Protoc, 2013;8(2):430-7.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells.
Authors: Singh A, Chappell J, Trost R, Lin L, Wang T, Tang J, Matlock B, Weller K, Wu H, Zhao S, Jin P, Dalton S
Stem Cell Reports, 2013;1(6):532-44.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential.
Authors: Duggal G, Heindryckx B, Warrier S, O'Leary T, Van der Jeught M, Lierman S, Vossaert L, Deroo T, Deforce D, Chuva de Sousa Lopes S, De Sutter P
Stem Cells Dev, 2013;22(23):3141-55.
Species: Human
Sample Type: whole cells
Application: Bioassay
Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
Cell Transplant, 2012;21(6):1321-39.
Species: Human
Sample Type: whole cells
Application: cell culture
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
Stem Cells Dev, 2012;21(12):2273-87.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
Nature, 2012;491(7426):765-8.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Authors: Mottershead D, Ritter L, Gilchrist R
Mol Hum Reprod, 2012;18(3):121-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
Authors: Joubin, Katherin, Richardson, Amelia, Novoa, Natalia, Tu, Edmund, Tomishima, Mark J
Stem Cells Dev, 2012;21(12):2312-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
Authors: Bruce D, Macartney T, Yong W, Shou W, Sapkota G
Cell Signal, 2012;24(11):1999-2006.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion.
Authors: Pereira P, Dobreva M, Maas E, Cornelis F, Moya I, Umans L, Verfaillie C, Camus A, de Sousa Lopes S, Huylebroeck D, Zwijsen A
Development, 2012;139(18):3343-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.
Authors: Sui L, Mfopou J, Geens M, Sermon K, Bouwens L
Biochem Biophys Res Commun, 2012;426(3):380-5.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
APELIN promotes hematopoiesis from human embryonic stem cells.
Blood, 2012;119(26):6243-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differentiation and transplantation of functional pancreatic beta cells generated from induced pluripotent stem cells derived from a type 1 diabetes mouse model.
Authors: Jeon, Kilsoo, Lim, Hyejin, Kim, Jung-Hyu, Thuan, Nguyen V, Park, Seung Hw, Lim, Yu-Mi, Choi, Hye-Yeon, Lee, Eung-Ryo, Kim, Jin-Hoi, Lee, Myung-Sh, Cho, Ssang-Go
Stem Cells Dev, 2012;21(14):2642-55.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cellular basis of tissue regeneration by omentum.
Authors: Shah S, Lowery E, Braun RK
PLoS ONE, 2012;7(6):e38368.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
Stem Cells, 2011;29(6):964-71.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
J. Biol. Chem., 2011;286(34):30034-46.
Species: Human
Sample Type: recombinant Endoglin
Application: Surface Plasmon Resonance
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Authors: Spence JR, Mayhew CN, Rankin SA
Nature, 2011;470(7332):105-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals.
Authors: Zhang Q, Jiang J, Han P, Yuan Q, Zhang J, Zhang X, Xu Y, Cao H, Meng Q, Chen L, Tian T, Wang X, Li P, Hescheler J, Ji G, Ma Y
Cell Res., 2011;21(4):579-87.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
Authors: Klim JR, Li L, Wrighton PJ
Nat. Methods, 2010;7(12):989-94.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Authors: Chng Z, Teo A, Pedersen RA, Vallier L
Cell Stem Cell, 2010;6(1):59-70.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.
Authors: Emre N, Vidal JG, Elia J
PLoS ONE, 2010;5(8):e12148.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm.
Authors: Chayosumrit M, Tuch B, Sidhu K
Biomaterials, 2010;31(3):505-14.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
Authors: Tramullas M, Lantero A, Diaz A, Morchon N, Merino D, Villar A, Buscher D, Merino R, Hurle JM, Izpisua-Belmonte JC, Hurle MA
J. Neurosci., 2010;30(4):1502-11.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
PLoS ONE, 2010;5(8):e12101.
Species: Human
Sample Type: Whole Cells
Application: differentiation
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Authors: Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
Cell Stem Cell, 2009;4(4):348-58.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis.
Authors: Dickinson RE, Stewart AJ, Myers M, Millar RP, Duncan WC
Endocrinology, 2009;150(6):2873-81.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
Authors: Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K
Stem Cells, 2009;27(2):341-51.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Scaffold-free human cardiac tissue patch created from embryonic stem cells.
Authors: Stevens KR, Pabon L, Muskheli V
Tissue Eng Part A, 2009;15(6):1211-22.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
Dev. Biol., 2009;330(2):286-304.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.
Authors: Jeanpierre S, Nicolini FE, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, Maguer-Satta V
Blood, 2008;112(8):3154-63.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature, 2008;453(7194):524-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
Authors: Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L
J. Biol. Chem., 2008;283(36):24991-5002.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell Stem Cell, 2008;2(6):602-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.
Authors: Shiraki N, Yoshida T, Araki K, Umezawa A, Higuchi Y, Goto H, Kume K, Kume S
Stem Cells, 2008;26(4):874-85.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells.
Authors: Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK
Biochem. Biophys. Res. Commun., 2007;366(1):129-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.
Authors: Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ
Blood, 2007;110(12):4111-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The activin A-follistatin system: potent regulator of human extracellular matrix mineralization.
Authors: Eijken M, Swagemakers S, Koedam M, Steenbergen C, Derkx P, Uitterlinden AG, van der Spek PJ, Visser JA, de Jong FH, Pols HA, van Leeuwen JP
FASEB J., 2007;21(11):2949-60.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stem cells derived from human fetal membranes display multilineage differentiation potential.
Authors: Ilancheran S, Michalska A, Peh G, Wallace EM, Pera M, Manuelpillai U
Biol. Reprod., 2007;77(3):577-88.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Lrp6 is required for convergent extension during Xenopus gastrulation.
Authors: Tahinci E, Thorne CA, Franklin JL, Salic A, Christian KM, Lee LA, Coffey RJ, Lee E
Development, 2007;134(22):4095-106.
Species: Xenopus
Sample Type: Whole Tissue
Application: Bioassay
The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Authors: Kupershmidt L, Amit T, Bar-Am O, Youdim MB, Blumenfeld Z
J. Neurochem., 2007;103(3):962-71.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Predicting evolutionary patterns of mammalian teeth from development.
Authors: Kavanagh KD, Evans AR, Jernvall J
Nature, 2007;449(7161):427-32.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.
Authors: McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S
Stem Cells, 2007;25(1):29-38.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
Authors: Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S
Cell, 2007;131(5):861-72.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Conditional gene expression in human embryonic stem cells.
Authors: Vallier L, Alexander M, Pedersen R
Stem Cells, 2007;25(6):1490-7.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Effect of insulin-like growth factor-binding protein 7 on steroidogenesis in granulosa cells derived from equine chorionic gonadotropin-primed immature rat ovaries.
Authors: Tamura K, Matsushita M, Endo A, Kutsukake M, Kogo H
Biol. Reprod., 2007;77(3):485-91.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.
Authors: Oki S, Hashimoto R, Okui Y, Shen MM, Mekada E, Otani H, Saijoh Y, Hamada H
Development, 2007;134(21):3893-904.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
New cell lines from mouse epiblast share defining features with human embryonic stem cells.
Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
Nature, 2007;448(7150):196-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
Authors: Alexander S, Watt F, Sawaji Y, Hermansson M, Saklatvala J
Arthritis Rheum., 2007;56(11):3715-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A large-scale proteomic analysis of human embryonic stem cells.
Authors: Schulz TC, Swistowska AM, Liu Y
BMC Genomics, 2007;8(0):478.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Prospective isolation and global gene expression analysis of definitive and visceral endoderm.
Authors: Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA
Dev. Biol., 2007;304(2):541-55.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
Authors: Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K
Stem Cells, 2006;24(9):2014-22.
Species: Primate - Callitrix jacchus (common marmoset)
Sample Type: Whole Cells
Application: Bioassay
Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
Authors: Greber B, Lehrach H, Adjaye J
Stem Cells, 2006;25(2):455-64.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
The activin-follistatin system and in vitro early follicle development in goats.
Authors: Silva JR, Tharasanit T, Taverne MA, van der Weijden GC, Santos RR, Figueiredo JR, van den Hurk R
J. Endocrinol., 2006;189(1):113-25.
Species: Goat
Sample Type: Whole Tissue
Application: Bioassay
The role of the activin system in keloid pathogenesis.
Authors: Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT
Am. J. Physiol., Cell Physiol., 2006;292(4):C1331-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions.
Authors: Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S
Proc. Natl. Acad. Sci. U.S.A., 2006;103(18):6907-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer.
Authors: Ng RK, Gurdon JB
Proc. Natl. Acad. Sci. U.S.A., 2005;102(6):1957-62.
Species: Xenopus
Sample Type: Whole Cells
Application: Bioassay
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
Authors: Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J
Arthritis Rheum., 2004;50(8):2521-30.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity.
Authors: Gilchrist RB, Ritter LJ, Cranfield M, Jeffery LA, Amato F, Scott SJ, Myllymaa S, Kaivo-Oja N, Lankinen H, Mottershead DG, Groome NP, Ritvos O
Biol. Reprod., 2004;71(3):732-9.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence.
Authors: Grimm OH, Gurdon JB
Nat. Cell Biol., 2002;4(7):519-22.
Species: Xenopus
Sample Type: Whole Cells
Application: Bioassay
Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures.
Authors: Kawakami S, Fujii Y, Okada Y, Winters SJ
Endocrinology, 2002;143(6):2250-8.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Whole Cells
Application: Bioassay

内毒素水平 <0.01 EU per 1 μg of the protein by the LAL method.
生物活性 Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. The ED50 for this effect is typically 0.2‑1.2 ng/mL.
The specific activity of Recombinant Human/Mouse/Rat Activin A is approximately 1 IU/μg, which is calibrated against human Activin A WHO International Standard (NIBSC code: 91/626).
溶解方法 Reconstitute at 100-500 μg/mL in sterile 4 mM HCl.
背景

Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16).

Accession # P08476
N-terminal
Sequence Analysis
Gly311
预期分子量 13 (monomer) kDa
SDS-PAGE 14 kDa, reducing conditions
24 kDa, non-reducing conditions
纯度 >95%, by SDS-PAGE with silver staining.
不含载体 What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

参考文献
  1. Kumanov, P. et al. (2005) Reprod. Biomed. Online 10:786.
  2. Maeshima, A. et al. (2008) Endocr. J. 55:1.
  3. Rodgarkia-Dara, C. et al. (2006) Mutat. Res. 613:123.
  4. Werner, S. and C. Alzheimer (2006) Cytokine Growth Factor Rev. 17:157.
  5. Xu, P. and A.K. Hall (2006) Dev. Biol. 299:303.
  6. Shav-Tal, Y. and D. Zipori (2002) Stem Cells 20:493.
  7. Chen, Y.G. et al. (2006) Exp. Biol. Med. 231:534.
  8. Gray, A.M. and A.J. Mason (1990) Science 247:1328.
  9. Mason, A.J. et al. (1996) Mol. Endocrinol. 10:1055.
  10. Thompson, T.B. et al. (2004) Mol. Cell. Endocrinol. 225:9.
  11. Harrison, C.A. et al. (2005) Trends Endocrinol. Metab. 16:73.
  12. Onichtchouk, D. et al. (1999) Nature 401:480.
  13. Gray, P.C. et al. (2002) Mol. Cell. Endocrinol. 188:254.
  14. Kelber, J.A. et al. (2008) J. Biol. Chem. 283:4490.
  15. Phillips, D.J. et al. (1997) J. Endocrinol. 155:65.
  16. Schneyer, A. et al. (2003) Endocrinology 144:1671.
参考图片
1 μg/lane of Recombinant Human/Mouse/Rat Activin A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 14 kDa and 24 kDa, respectively.
BG01V human embryonic stem cells were differentiated into endoderm using media supplemented with Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC). Control cells were cultured in medium without recombinant Activin A. Differentiation into endoderm was confirmed by positive-staining for Claudin-6 (red) and Sox17 (green) using the Mouse Anti-Human Claudin-6 Monoclonal Antibody (Catalog # MAB3656) and the Goat Anti-Human Sox17 Polyclonal Antibody (Catalog # AF1924), respectively. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.
Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC) induces hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 is typically 0.2‑1.2 ng/mL.
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