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Recombinant Human FGF basic (146 aa) Protein

(233-FB-025)



概述
货号 233-FB-025
别名 basic fibroblast growth factor bFGF; Basic fibroblast growth factor; bFGF; FGF2; FGF-2; FGF2AS; FGFBprostatropin; fibroblast growth factor 2 (basic); GFG1; HBGF-2; HBGH-2; heparin-binding growth factor 2; NUDT6; Prostatropin
全称 Fibroblast Growth Factor basic
反应种属 Human
形式 Lyophilized from a 0.2 μm filtered solution in Tris-HCl and NaCl with BSA as a carrier protein.
性能
供应商 R&D Systems
Entrez Gene IDs 2247 (Human); 14173 (Mouse); 281161 (Bovine); 403857 (Canine); 100033955 (Equine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Endothelial heparan sulfate 6-o-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.
Authors: Ferreras, Cristina, Rushton, Graham, Cole, Claire L, Babur, Muhammad, Telfer, Brian A, van Kuppevelt, Toin H, Gardiner, John M, Williams, Kaye J, Jayson, Gordon C, Avizienyte, Egle
J Biol Chem, 2102;287(43):36132-46.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination with Cell Polarization During Ameloblast Differentiation
J Bone Miner Res, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
Authors: Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, Segarra M, Eberhart C, Acker-Palmer A, Tosato G
Nat Commun, 2015;6(0):6576.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
mTOR inhibition improves fibroblast growth factor receptor targeting in hepatocellular carcinoma.
Authors: Scheller, T, Hellerbrand, C, Moser, C, Schmidt, K, Kroemer, A, Brunner, S M, Schlitt, H J, Geissler, E K, Lang, S A
Br J Cancer, 2015;112(5):841-50.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Prolonged and tunable residence time using reversible covalent kinase inhibitors.
Authors: Bradshaw J, McFarland J, Paavilainen V, Bisconte A, Tam D, Phan V, Romanov S, Finkle D, Shu J, Patel V, Ton T, Li X, Loughhead D, Nunn P, Karr D, Gerritsen M, Funk J, Owens T, Verner E, Brameld K, Hill R, Goldstein D, Taunton J
Nat Chem Biol, 2015;11(7):525-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells.
Authors: Iyer D, Gambardella L, Bernard W, Serrano F, Mascetti V, Pedersen R, Talasila A, Sinha S
Development, 2015;142(8):1528-41.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The schizophrenia risk gene product miR-137 alters presynaptic plasticity.
Authors: Siegert S, Seo J, Kwon E, Rudenko A, Cho S, Wang W, Flood Z, Martorell A, Ericsson M, Mungenast A, Tsai L
Nat Neurosci, 2015;18(7):1008-16.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model.
Authors: Chen C, Cheng F, Su H, Sheu M, Lu Z, Chiang C, Yang D, Sheehan J, Pan H
PLoS ONE, 2015;10(5):e0124624.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3.
Authors: Granata A, Bernard W, Zhao N, McCafferty J, Lilly B, Sinha S
Stem Cells Dev, 2015;24(7):846-56.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.
Authors: Wu, Bo, Cao, Xiaoming, Liang, Xuezhi, Zhang, Xuhui, Zhang, Wei, Sun, Guang, Wang, Dongwen
PLoS ONE, 2015;10(1):e0117510.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Mitochondrial control by DRP1 in brain tumor initiating cells.
Authors: Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Shi Y, Ferguson A, Kashatus D, Bao S, Rich J
Nat Neurosci, 2015;18(4):501-10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
Authors: All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C
PLoS ONE, 2015;10(1):e0116933.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.
Authors: Deverman B, Pravdo P, Simpson B, Kumar S, Chan K, Banerjee A, Wu W, Yang B, Huber N, Pasca S, Gradinaru V
Nat Biotechnol, 2015;34(2):204-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cellular Responses Modulated by FGF-2 Adsorbed on Albumin/Heparin Layer-by-Layer Assemblies.
Authors: Kumorek M, Kubies D, Filova E, Houska M, Kasoju N, Mazl Chanova E, Matejka R, Kryslova M, Bacakova L, Rypacek F
PLoS ONE, 2015;10(5):e0125484.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
The evidence of glioblastoma heterogeneity.
Authors: Soeda, Akio, Hara, Akira, Kunisada, Takahiro, Yoshimura, Shin-ich, Iwama, Toru, Park, Deric M
Sci Rep, 2015;5(0):7979.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
Nat Protoc, 2015;10(3):413-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment.
Authors: Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R, Le Bourhis X
Stem Cells, 2015;33(2):342-53.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia.
Authors: Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf N, Wang H, Silverman R, Ayata C, Maxwell M, Steegborn C, Schwarzschild M, Outeiro T, Kazantsev A
PLoS ONE, 2015;10(1):e0116919.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Endophilin marks and controls a clathrin-independent endocytic pathway.
Authors: Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
Nature, 2015;517(7535):460-5.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Authors: Shen K, Luk S, Hicks D, Elman J, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush M, Toner M, Sgroi D, Parekkadan B
Nat Commun, 2014;5(0):5662.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa.
Authors: Tolar J, McGrath J, Xia L, Riddle M, Lees C, Eide C, Keene D, Liu L, Osborn M, Lund T, Blazar B, Wagner J
J Invest Dermatol, 2014;134(5):1246-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
PLoS ONE, 2014;9(12):e116114.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.
Authors: Adini, Irit, Ghosh, Kaustabh, Adini, Avner, Chi, Zai-Long, Yoshimura, Takeru, Benny, Ofra, Connor, Kip M, Rogers, Michael, Bazinet, Lauren, Birsner, Amy E, Bielenberg, Diane R, D'Amato, Robert J
J Clin Invest, 2014;124(1):425-36.
Species: Human
Sample Type: whole cells
Application: cell culture
Transcriptional profiling of adult neural stem-like cells from the human brain.
Authors: Sandberg C, Vik-Mo E, Behnan J, Helseth E, Langmoen I
PLoS ONE, 2014;9(12):e114739.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Brivanib attenuates hepatic fibrosis in vivo and stellate cell activation in vitro by inhibition of FGF, VEGF and PDGF signaling.
Authors: Nakamura I, Zakharia K, Banini B, Mikhail D, Kim T, Yang J, Moser C, Shaleh H, Thornburgh S, Walters I, Roberts L
PLoS ONE, 2014;9(4):e92273.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
Authors: Flierl A, Oliveira L, Falomir-Lockhart L, Mak S, Hesley J, Soldner F, Arndt-Jovin D, Jaenisch R, Langston J, Jovin T, Schule B
PLoS ONE, 2014;9(11):e112413.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Selective calcium sensitivity in immature glioma cancer stem cells.
Authors: Wee S, Niklasson M, Marinescu V, Segerman A, Schmidt L, Hermansson A, Dirks P, Forsberg-Nilsson K, Westermark B, Uhrbom L, Linnarsson S, Nelander S, Andang M
PLoS ONE, 2014;9(12):e115698.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation.
Authors: Gerhardt J, Zaninovic N, Zhan Q, Madireddy A, Nolin S, Ersalesi N, Yan Z, Rosenwaks Z, Schildkraut C
J Cell Biol, 2014;206(5):599-607.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy.
Authors: Yan K, Wu Q, Yan D, Lee C, Rahim N, Tritschler I, DeVecchio J, Kalady M, Hjelmeland A, Rich J
Genes Dev, 2014;28(10):1085-100.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Genetic background drives transcriptional variation in human induced pluripotent stem cells.
Authors: Rouhani, Foad, Kumasaka, Natsuhik, de Brito, Miguel C, Bradley, Allan, Vallier, Ludovic, Gaffney, Daniel
PLoS Genet, 2014;10(6):e1004432.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Tissue-engineered vascular grafts created from human induced pluripotent stem cells.
Authors: Sundaram S, One J, Siewert J, Teodosescu S, Zhao L, Dimitrievska S, Qian H, Huang A, Niklason L
Stem Cells Transl Med, 2014;3(12):1535-43.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells.
Authors: Brady M, Hilchey S, Hyrien O, Spence S, Bernstein S
PLoS ONE, 2014;9(5):e97597.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells.
Authors: Tani, Hidenori, Onuma, Yasuko, Ito, Yuzuru, Torimura, Masaki
PLoS ONE, 2014;9(8):e106282.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant.
Authors: Takebe, Takanori, Zhang, Ran-Ran, Koike, Hiroyuki, Kimura, Masaki, Yoshizawa, Emi, Enomura, Masahiro, Koike, Naoto, Sekine, Keisuke, Taniguchi, Hideki
Nat Protoc, 2014;9(2):396-409.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study.
Authors: Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J
Respir Res, 2014;15(0):39.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors.
Authors: Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S
PLoS ONE, 2014;9(9):e106901.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Histone hyperacetylation up-regulates protein kinase Cdelta in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
Authors: Jin H, Kanthasamy A, Harischandra D, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy A
J Biol Chem, 2014;289(50):34743-67.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Distinct effects of ligand-induced PDGFRalpha and PDGFRbeta signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments.
Authors: Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Ostman A, Eriksson U
Cancer Res, 2013;73(7):2139-49.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
Authors: Smith A, Bowers S, Stratman A, Davis G
PLoS ONE, 2013;8(12):e85147.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model.
Authors: Chen Y, Huang W, Chang S, Chang K, Kao S, Lo J, Su P
Oncol Rep, 2013;30(6):2829-37.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Production of hepatocyte-like cells from human pluripotent stem cells.
Authors: Hannan, Nicholas, Segeritz, Charis-P, Touboul, Thomas, Vallier, Ludovic
Nat Protoc, 2013;8(2):430-7.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
alpha-Synuclein oligomers impair neuronal microtubule-kinesin interplay.
Authors: Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Bohm K, Winner B
J Biol Chem, 2013;288(30):21742-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.
Authors: Lotti, Fiorenza, Jarrar, Awad M, Pai, Rish K, Hitomi, Masahiro, Lathia, Justin, Mace, Adam, Gantt, Gerald A, Sukhdeo, Kumar, DeVecchio, Jennifer, Vasanji, Amit, Leahy, Patrick, Hjelmeland, Anita B, Kalady, Matthew, Rich, Jeremy N
J Exp Med, 2013;210(13):2851-72.
Species: Human
Sample Type: whole cells
Application: Bioassay
Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.
Authors: Cheung C, Bernardo AS, Trotter MW
Nat. Biotechnol., 2012;30(2):165-73.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Fibroblast growth factor-2 maintains a niche-dependent population of self-renewing highly potent non-adherent mesenchymal progenitors through FGFR2c.
Authors: Di Maggio N, Mehrkens A, Papadimitropoulos A, Schaeren S, Heberer M, Banfi A, Martin I
Stem Cells, 2012;30(7):1455-64.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012;7(4):e34965.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Non-canonical TAF complexes regulate active promoters in human embryonic stem cells.
Authors: Maston G, Zhu L, Chamberlain L, Lin L, Fang M, Green M
Elife, 2012;1(0):e00068.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Authors: Segarra, Marta, Ohnuki, Hidetaka, Maric, Dragan, Salvucci, Ombretta, Hou, Xu, Kumar, Anil, Li, Xuri, Tosato, Giovanna
Blood, 2012;120(19):4104-15.
Species: Human
Sample Type: whole cells
Application: Bioassay
The endothelial cell line bEnd.3 maintains human pluripotent stem cells.
Authors: Joubin, Katherin, Richardson, Amelia, Novoa, Natalia, Tu, Edmund, Tomishima, Mark J
Stem Cells Dev, 2012;21(12):2312-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differentiation potential of human postnatal mesenchymal stem cells, mesoangioblasts, and multipotent adult progenitor cells reflected in their transcriptome and partially influenced by the culture conditions.
Authors: Roobrouck VD, Clavel C, Jacobs SA, Ulloa-Montoya F, Crippa S, Sohni A, Roberts SJ, Luyten FP, Van Gool SW, Sampaolesi M, Delforge M, Luttun A, Verfaillie CM
Stem Cells, 2011;29(5):871-82.
Species: Human
Sample Type: Whole Tissue
Application: Bioassay
Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.
Authors: Fang JD, Chou HC, Tung HH
J. Biol. Chem., 2011;286(7):5667-79.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dentin matrix protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation.
Authors: Pirotte S, Lamour V, Lambert V, Alvarez Gonzalez ML, Ormenese S, Noel A, Mottet D, Castronovo V, Bellahcene A
Blood, 2011;117(8):2515-26.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres.
Authors: Walter D, Satheesha S, Albrecht P, Bornhauser BC, D'Alessandro V, Oesch SM, Rehrauer H, Leuschner I, Koscielniak E, Gengler C, Moch H, Bernasconi M, Niggli FK, Schafer BW
PLoS ONE, 2011;6(5):e19506.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Specification of transplantable astroglial subtypes from human pluripotent stem cells.
Authors: Krencik R, Weick JP, Liu Y, Zhang ZJ, Zhang SC
Nat. Biotechnol., 2011;29(6):528-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells.
Authors: Chng Z, Teo A, Pedersen RA, Vallier L
Cell Stem Cell, 2010;6(1):59-70.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.
Authors: Carvajal-Vergara X, Sevilla A, D'Souza SL
Nature, 2010;465(7299):808-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.
Authors: Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ
Brain, 2010;133(0):2232-47.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
PLoS ONE, 2010;5(8):e12101.
Species: Human
Sample Type: Whole Cells
Application: Expansion/Differentiation
Selection and characterization of a human neutralizing antibody to human fibroblast growth factor-2.
Authors: Tao J, Xiang JJ, Li D, Deng N, Wang H, Gong YP
Biochem. Biophys. Res. Commun., 2010;394(3):767-73.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice.
Authors: Floer M, Gotte M, Wild MK, Heidemann J, Gassar ES, Domschke W, Kiesel L, Luegering A, Kucharzik T
Am. J. Pathol., 2010;176(1):146-57.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition.
Authors: Yang MH, Hsu DS, Wang HW
Nat. Cell Biol., 2010;12(10):982-92.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.
Authors: Bernardo AS, Cho CH, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K
Stem Cells, 2009;27(2):341-51.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease.
Authors: Darby S, Murphy T, Thomas H, Robson CN, Leung HY, Mathers ME, Gnanapragasam VJ
Br. J. Cancer, 2009;101(11):1891-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos.
Authors: Ma LH, Webb SE, Chan CM, Zhang J, Miller AL
Dev. Biol., 2009;327(1):143-57.
Species: Zebrafish
Sample Type: Whole Cells
Application: Bioassay
Mitogen-activated protein kinase-signaling regulates the ability of Muller glia to proliferate and protect retinal neurons against excitotoxicity.
Authors: Fischer AJ, Scott MA, Ritchey ER, Sherwood P
Glia, 2009;57(14):1538-52.
Species: Chicken
Sample Type: In Vivo
Application: In Vivo
Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
Int. J. Cancer, 2009;125(5):1092-101.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Growth factor regulation of growth factors in articular chondrocytes.
Authors: Shi S, Mercer S, Eckert GJ, Trippel SB
J. Biol. Chem., 2009;284(11):6697-704.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Distinctions between fetal and adult human platelet-derived growth factor-responsive neural precursors.
Authors: Chojnacki A, Kelly JJ, Hader W, Weiss S
Ann. Neurol., 2008;64(2):127-42.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
Stem Cells, 2008;26(7):1705-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Characterization of human skin-derived mesenchymal stem cell proliferation rate in different growth conditions.
Authors: Riekstina U, Muceniece R, Cakstina I, Muiznieks I, Ancans J
Cytotechnology, 2008;58(3):153-62.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Musashi1 RNA-binding protein regulates oligodendrocyte lineage cell differentiation and survival.
Authors: Dobson NR, Zhou YX, Flint NC, Armstrong RC
Glia, 2008;56(3):318-30.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells.
Authors: Desbordes SC, Placantonakis DG, Ciro A, Socci ND, Lee G, Djaballah H, Studer L
Cell Stem Cell, 2008;2(6):602-12.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Efficient Serum-Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell-Enriched Cultures.
Authors: Rao RC, Boyd J, Padmanabhan R, Chenoweth JG, McKay RD
Stem Cells, 2008;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.
Authors: Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP
J. Biol. Chem., 2008;283(14):9308-17.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery.
Authors: Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE
J. Cell Biol., 2008;180(5):897-904.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Authors: Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature, 2008;453(7194):524-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
MDR1 expression identifies human melanoma stem cells.
Authors: Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, Treves AJ, Schachter J, Amariglio N, Rechavi G
Biochem. Biophys. Res. Commun., 2008;368(4):930-6.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A CXCL5- and bFGF-dependent effect of PDGF-B-activated fibroblasts in promoting trafficking and differentiation of bone marrow-derived mesenchymal stem cells.
Authors: Nedeau AE, Bauer RJ, Gallagher K, Chen H, Liu ZJ, Velazquez OC
Exp. Cell Res., 2008;314(11):2176-86.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
Genes Dev., 2008;22(2):152-65.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed.
Authors: McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S
Stem Cells, 2007;25(1):29-38.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation.
Authors: Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WS, Yang CY, Chen CH
Diabetes, 2007;57(1):158-66.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Authors: Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF
Stem Cells, 2007;25(2):490-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
J. Biol. Chem., 2007;282(43):31643-55.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Role for amplification and expression of glypican-5 in rhabdomyosarcoma.
Authors: Williamson D, Selfe J, Lu YJ, Pritchard-Jones K, Murai K, Jones P, Workman P, Shipley J
Cancer Res., 2007;67(1):57-65.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.
Authors: Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ
Blood, 2007;110(12):4111-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research.
Authors: Josephson R, Ording CJ, Liu Y, Shin S, Lakshmipathy U, Toumadje A, Love B, Chesnut JD, Andrews PW, Rao MS, Auerbach JM
Stem Cells, 2007;25(2):437-46.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Conditional gene expression in human embryonic stem cells.
Authors: Vallier L, Alexander M, Pedersen R
Stem Cells, 2007;25(6):1490-7.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
Nature, 2007;450(7171):825-31.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
New cell lines from mouse epiblast share defining features with human embryonic stem cells.
Authors: Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL, McKay RD
Nature, 2007;448(7150):196-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
Authors: Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP
Development, 2007;134(23):4177-86.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differentiation of ES cells into cerebellar neurons.
Authors: Salero E, Hatten ME
Proc. Natl. Acad. Sci. U.S.A., 2007;104(8):2997-3002.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Long-term maintenance of brain tumor stem cell properties under at non-adherent and adherent culture conditions.
Authors: Inagaki A, Soeda A, Oka N, Kitajima H, Nakagawa J, Motohashi T, Kunisada T, Iwama T
Biochem. Biophys. Res. Commun., 2007;361(3):586-92.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
Blood, 2007;111(4):1933-41.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Fractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis.
Authors: You JJ, Yang CH, Huang JS, Chen MS, Yang CM
Invest. Ophthalmol. Vis. Sci., 2007;48(11):5290-8.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
A large-scale proteomic analysis of human embryonic stem cells.
Authors: Schulz TC, Swistowska AM, Liu Y
BMC Genomics, 2007;8(0):478.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Expression of leukemia inhibitory factor and its receptors is increased during differentiation of human embryonic stem cells.
Authors: Aghajanova L, Skottman H, Stromberg AM, Inzunza J, Lahesmaa R, Hovatta O
Fertil. Steril., 2006;86(4):1193-209.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1.
Authors: Lake AC, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret GY, Letourneur D
J. Biol. Chem., 2006;281(49):37844-52.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Monocytes/macrophages cooperate with progenitor cells during neovascularization and tissue repair: conversion of cell columns into fibrovascular bundles.
Authors: Anghelina M, Krishnan P, Moldovan L, Moldovan NI
Am. J. Pathol., 2006;168(2):529-41.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Authors: Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
Br. J. Haematol., 2006;135(5):703-14.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells.
Authors: Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A
Blood, 2006;107(5):1896-902.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
Authors: Greber B, Lehrach H, Adjaye J
Stem Cells, 2006;25(2):455-64.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Re-growth of catecholaminergic fibers and protection of cholinergic spinal cord neurons in spinal repaired rats.
Authors: Lee YS, Lin CY, Robertson RT, Yu J, Deng X, Hsiao I, Lin VW
Eur. J. Neurosci., 2006;23(3):693-702.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
Authors: Nakayama T, Mutsuga N, Tosato G
Blood, 2006;109(4):1363-72.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium.
Authors: Bartunek J, Croissant JD, Wijns W, Gofflot S, de Lavareille A, Vanderheyden M, Kaluzhny Y, Mazouz N, Willemsen P, Penicka M, Mathieu M, Homsy C, De Bruyne B, McEntee K, Lee IW, Heyndrickx GR
Am. J. Physiol. Heart Circ. Physiol., 2006;292(2):H1095-104.
Species: Canine
Sample Type: Whole Cells
Application: Bioassay
Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
Glia, 2006;53(8):845-57.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells.
Authors: Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K
Stem Cells, 2006;24(9):2014-22.
Species: Primate - Callitrix jacchus (common marmoset)
Sample Type: Whole Cells
Application: Bioassay
Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm.
Authors: Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM
Development, 2006;133(19):3787-96.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Isolation of a novel population of multipotent adult stem cells from human hair follicles.
Authors: Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X
Am. J. Pathol., 2006;168(6):1879-88.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
J. Invest. Dermatol., 2006;126(9):2096-105.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Multipotent adult progenitor cells from swine bone marrow.
Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
Stem Cells, 2006;24(11):2355-66.
Species: Porcine
Sample Type: Whole Cells
Application: Bioassay
Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
Authors: Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M
J. Neurochem., 2006;98(1):45-56.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Authors: Narazaki M, Tosato G
Blood, 2006;107(10):3892-901.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Neural conversion of human embryonic stem cell colonies in the presence of fibroblast growth factor-2.
Authors: Benzing C, Segschneider M, Leinhaas A, Itskovitz-Eldor J, Brustle O
Neuroreport, 2006;17(16):1675-81.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Intracerebral infusion of glial cell line-derived neurotrophic factor promotes striatal neurogenesis after stroke in adult rats.
Authors: Kobayashi T, Ahlenius H, Thored P, Kobayashi R, Kokaia Z, Lindvall O
Stroke, 2006;37(9):2361-7.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy.
Authors: Bagley RG, Weber W, Rouleau C, Teicher BA
Cancer Res., 2005;65(21):9741-50.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005;203(1):35-43.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Muller glia in the chicken retina.
Authors: Fischer AJ, Omar G
J. Comp. Neurol., 2005;484(1):1-14.
Species: Chicken
Sample Type: In Vivo
Application: In Vivo
Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis.
Authors: Shin JW, Min M, Larrieu-Lahargue F, Canron X, Kunstfeld R, Nguyen L, Henderson JE, Bikfalvi A, Detmar M, Hong YK
Mol. Biol. Cell, 2005;17(2):576-84.
Species: Human
Sample Type: Whole Cells

Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effects.
Authors: Kim B, Lee S, Suvas S, Rouse BT
J. Immunol., 2005;175(1):509-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis.
Authors: Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP
Development, 2005;132(6):1223-34.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Clonal amniotic fluid-derived stem cells express characteristics of both mesenchymal and neural stem cells.
Authors: Tsai MS, Hwang SM, Tsai YL, Cheng FC, Lee JL, Chang YJ
Biol. Reprod., 2005;74(3):545-51.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Novel regulators of kidney development from the tips of the ureteric bud.
Authors: Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Lu B, Costantini F, Schiffer M, Bottinger E, Barasch J
J. Am. Soc. Nephrol., 2005;16(7):1993-2002.
Species: Rat
Sample Type: Whole Tissue
Application: Bioassay
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts.
Authors: Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J
Arthritis Rheum., 2004;50(8):2521-30.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Growth differentiation factor-9 and stem cell factor promote primordial follicle formation in the hamster: modulation by follicle-stimulating hormone.
Authors: Wang J, Roy SK
Biol. Reprod., 2004;70(3):577-85.
Species: Hamster
Sample Type: Whole Cells
Application: Bioassay
Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5.
Authors: Sharma MR, Tuszynski GP, Sharma MC
J. Cell. Biochem., 2004;91(2):398-409.
Species: Bovine
Sample Type: Whole Cells
Application: Bioassay
High-level expression of functional chemokine receptor CXCR4 on human neural precursor cells.
Authors: Ni HT, Hu S, Sheng WS, Olson JM, Cheeran MC, Chan AS, Lokensgard JR, Peterson PK
Brain Res. Dev. Brain Res., 2004;152(2):159-69.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage.
Authors: Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA
Mol. Vis., 2004;10(0):973-86.
Species: Chicken
Sample Type: In Vivo
Application: In Vivo
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
Blood, 2004;104(2):314-20.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity.
Authors: Yi M, Sakai T, Fassler R, Ruoslahti E
Proc. Natl. Acad. Sci. U.S.A., 2003;100(20):11435-8.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation.
Authors: Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R
J. Biol. Chem., 2003;278(16):14087-91.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3.
Authors: Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC
Cancer Res., 2003;63(4):887-92.
Species: Human
Sample Type: Whole Cells
Application: Binding Assay
Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells.
Authors: Bandyopadhyay A, Zhu Y, Malik SN, Kreisberg J, Brattain MG, Sprague EA, Luo J, Lopez-Casillas F, Sun LZ
Oncogene, 2002;21(22):3541-51.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Regulation of alpha(v)beta3 and alpha5beta1 integrin receptors by basic fibroblast growth factor and platelet-derived growth factor-BB in intrasynovial flexor tendon cells.
Authors: Harwood FL, Goomer RS, Gelberman RH, Silva MJ, Amiel D
Wound Repair Regen, 1999;7(5):381-8.
Species: Canine
Sample Type: Whole Cells
Application: Bioassay

内毒素水平 <0.10 EU per 1 μg of the protein by the LAL method.
生物活性 Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Raines, E.W. et al. (1985) Methods Enzymol. 109:749. The ED50 for this effect is typically 0.1-0.6 ng/mL.
The specific activity of Recombinant Human FGF basic is approximately 800 IU/μg, which is calibrated against recombinant human FGF basic WHO International Standard (NIBSC code: 90/712).
溶解方法 Reconstitute at 100-250 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
背景

FGF basic is a member of the FGF family of at least 23 related mitogenic proteins which show 35-60% amino acid conservation. FGF acidic and basic, unlike the other members of the family, lack signal peptides and are apparently secreted by mechanisms other than the classical protein secretion pathway. FGF basic has been isolated from a number of sources, including neural tissue, pituitary, adrenal cortex, corpus luteum, and placenta. This factor contains four cysteine residues, but reduced FGF basic retains full biological activity, indicating that disulfide bonds are not required for this activity. A variety of forms of FGF basic are produced as a result of N-terminal extensions. These extensions affect localization of FGF basic in cellular compartments but do not affect biological activity. Binding of FGF to heparin or cell surface heparan sulfate proteoglycans is necessary for binding of FGF to high affinity FGF receptors. FGF acidic and basic appear to bind to the same high affinity receptors and show a similar range of biological activities. FGF basic stimulates the proliferation of all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. FGF basic induces neuron differentiation, survival, and regeneration. FGF basic also modulates embryonic development and differentiation. These observed in vitro functions of FGF basic suggest FGF basic may play a role in vivo in the modulation of such normal processes as angiogenesis, wound healing and tissue repair, embryonic development and differentiation, and neuronal function and neural degeneration. Additionally, FGF basic may participate in the production of a variety of pathological conditions resulting from excessive cell proliferation and excessive angiogenesis.

Accession # P09038
N-terminal
Sequence Analysis
Ala-Pro143
预期分子量 16.5 kDa
SDS-PAGE 17 kDa, reducing conditions
纯度 >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
不含载体 What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

参考文献
  1. Coulier, F. et al. (1997) J. Mol. Evol. 44:43.
  2. Chen, C.H. et al. (2004) Curr. Vasc. Pharmacol. 2:33.
  3. Mohammadi, M. et al. (2005) Curr. Opin. Struct. Biol. 15:506.
  4. Fernig, D. et al. (1994) Prog. Growth Factor Res. 5:353.
参考图片
1 µg/lane of Recombinant Human FGF basic (146 aa) was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.
Recombinant Human FGF basic (146aa) (Catalog # 233-FB) stimulates cell proliferation of the NR6R‑3T3 mouse fibroblast cell line. The ED50 for this effect is typically 0.1-0.6 ng/mL.
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您还需要准备一份随样单(合同附件所示),标注您的姓名、合同号、样本信息、试剂信息,随快递一起寄送。

若由于您运输条件的原因,导致实验结果问题,相关责任由您承担。

实验室接收样本联系方式,提供寄送咨询: labex@univ-bio.com4008-168-0683

2)若您需要我们协助寄送样本时,我们会收取合理的寄送费用,以我们标准合同上所列收费为准。

4.实验服务合同结束后样本和试剂处置须知:

请您下单前确定实验服务合同结束后,样本处置情况。我们将严格按照合同约定执行。若您选择实验结束后样本,不保留,丢弃,我们会在实验结束后按国家标准自行处置掉相关实验材料。若您需要回寄相关样本,在您支付一定的运输费用后,我们将剩余样本在规定时间内返还给您。若您选择到付,需要保证您的样本是常温和蓝冰运输的,更高要求的运输条件不支持货到付款。若您不确定是否回寄,我们将保持您的样本1个月的时间,如超期,样本我们将自行处置,不在另行通知您。 如果您选择我们回寄样本给您,我们将快递信息邮件告知您,由您跟踪物流信息,并及时确认。如因您个人原因或者第三方物流原因造成的样本邮寄过程中的损耗,我们不承担任何责任。

5.实验服务种实验服务数据:

1) 我们承诺按照《实验样本信息及要求》中的实验方案进行实验并提供客观实验结果,但由于科研实验中存在诸多不确定因素以及未知难度和风险而导致结果的不确定性,不能保证所有的实验进度和实验结果完全达到甲方预期。在排除实验操作问题导致不良结果的前提下,您应尊重客观事实,承担实验结果与预期不一致的结果,包括实验结果是阴性的风险。因此在得不到预期结果的情况下,您仍应支付本次实验服务的全部已发生费用。

2) 实验服务是由专业技术达标的实验人员,遵循科学实验方法和标准操作流程,依照服务合同完成,优宁维保证将客观真实科学严谨的实验结果给到客户,但单次实验不足以阐明某些复杂的科学问题。

3) 您在收到实验数据后,5个工作日内(荧光相关实验3个工作日内)对实验数据质量提质疑,我们有义务解答。若是我们实验过程中的问题,我们承担全部责任;若是您验设计问题,您承担全部责任。我们承诺1个月的数据复核期,欢迎后续咨询。

6.客户知识产权保密协议:

1) 实验服务过程中产生的实验数据的知识产权归您所有,我们承诺不得以任何形式向除甲方以外的第三方提供该实验数据。对于相关的实验技术所有权归我们所有,您不得主张权利。

2) 我们双方共同致力于维护对方的商业机密和技术机密,包括本次合同所签订的文件,您都有义务进行保密。

7.服务承诺

如由于实验客观性需要重复实验、自然灾害、政府行为或其他乙方无法预见、无法避免和无法克服等不可抗力的客观原因造成合同无法按期履行的,我们将及时通知甲方,双方将视情况决定是否继续履行合同。如果由于客观原因造成某些实验项目不能执行的,合同结束时,退回相应款项。

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