EUK 134-小分子化合物-添加剂-优宁维细胞/细胞培养平台
EUK 134
货号: 10006329-100mg 品牌: Cayman 分子式:
C18H18ClMnN2O4
C18H18ClMnN2O4
规格: 100mg
产品说明书
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价格: ¥ 5256.30

目录价: ¥5256.30

数量
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概述
描述
Synthetic manganese-porphyrin complexes have been documented to act as scavengers for oxidative species such as peroxynitrite, superoxide, and hydrogen peroxide. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK 134 consumes hydrogen peroxide with an initial reaction rate of 234 µM/min in vitro. 1 EUK 134 is protective in a rat stroke model, employing middle cerebral artery ligation. At 2.5 mg/kg, rats treated with EUK 134 showed reduced infarct volume by more than 80%. EUK 134 at 10 mg/kg also significantly attenuates brain damage in rats following systemic administration of kainic acid. 2
是否允许进口
允许
是否危险品
非危险品
性能
供应商
Cayman
应用文献
1.Baker, K.,Marcus, C.B.,Huffman, K., et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. Journal of Pharmacology and Experimental Therapeutics 284(1), 215-221 (1998).
2.Rong, Y.,Doctrow, S.R.,Tocco, G., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proceedings of the National Academy of Sciences of the United States of America 96, 9897-9902 (1999).
存放说明
-20
纯度
≥98%
计算分子量
416.7
分子式
C18H18ClMnN2O4
CAS号
81065-76-1
原产地
UNITED STATES
稳定性
≥ 1 year

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