rh/m/rActivin A (500 UG)-细胞因子-2D/3D培养-优宁维细胞/细胞培养平台
rh/m/rActivin A (500 UG)
货号: 338-AC-500 品牌: R&D Systems
规格: 500UG
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价格: ¥ 52593.00

目录价: ¥52593.00

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概述
别名
Activin A; INHBA
形式
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
是否允许进口
允许
是否危险品
非危险品
性能
供应商
R&D Systems
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology
Authors: K Sakamoto, Y Kanematsu-, Y Kamada, M Oka, T Ohnishi, M Miwa, T Asami, H Inooka
Biochem Biophys Rep, 2017;11(0):33-39.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF? and Activin pathways
Authors: M García, R Barrio, M García-Lav, AR Garcia-Ren, A Escudero, E Díaz-Rodrí, D Gorbenko D, A Fernández, YB de Rijke, E Vallespín, J Nevado, P Lapunzina, V Matre, PM Hinkle, AC Hokken-Koe, MP de Miguel, JM Cameselle-, M Nistal, CV Alvarez, JC Moreno
Sci Rep, 2017;7(0):42937.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva
Authors: K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya
J. Clin. Invest., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
In Vitro Micropatterned Human Pluripotent Stem Cell Test (�P-hPST) for Morphometric-Based Teratogen Screening
Authors: J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu
Sci Rep, 2017;7(1):8491.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity
Authors: S Merfeld-Cl, H Lu, X Wu, KL March, DO Traktuev
J. Cell. Mol. Med., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells
Authors: F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier
Nat Protoc, 2017;12(4):814-827.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Supraphysiological levels of GDF11 induce striated muscle atrophy
Authors: DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney
EMBO Mol Med, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses
Authors: S Tousa, M Semitekolo, I Morianos, A Banos, AI Trochoutso, TM Brodie, N Poulos, K Samitas, M Kapasa, D Konstantop, G Paraskevop, M Gaga, CM Hawrylowic, F Sallusto, G Xanthou
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci
Authors: EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru
Cell Stem Cell, 2017;20(4):558-570.e10.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System
Authors: K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differentiation and characterization of rhesus monkey atrial and ventricular cardiomyocytes from induced pluripotent stem cells
Authors: X Zhang, H Cao, S Bai, W Huo, Y Ma
Stem Cell Res, 2017;20(0):21-29.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
Nat Commun, 2017;8(0):14127.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors
Authors: G Valenti, HM Quinn, GJ Heynen, L Lan, JD Holland, R Vogel, A Wulf-Golde, W Birchmeier
Cancer Res, 2017;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse
Authors: B Ulmer, M Tingler, S Kurz, M Maerker, P Andre, D Mönch, M Campione, K Dei beta ler, M Lewandoski, T Thumberger, A Schweicker, A Fainsod, H Steinbei beta e, M Blum
Sci Rep, 2017;7(0):43010.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
In�Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling
Authors: K Yamamizu, M Iwasaki, H Takakubo, T Sakamoto, T Ikuno, M Miyoshi, T Kondo, Y Nakao, M Nakagawa, H Inoue, JK Yamashita
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells
Authors: T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee
Sci Rep, 2017;7(0):41304.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity
Authors: Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan
Sci Rep, 2017;7(0):41238.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration
Authors: JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang, NC Boles, TA Blenkinsop, JH Stern, S Temple
Cell Stem Cell, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo
Authors: S Stayte, P Rentsch, AR Tr”scher, M Bamberger, KM Li, B Vissel
PLoS ONE, 2017;12(1):e0167211.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells
Nat Protoc, 2017;12(1):195-207.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells
Nat Protoc, 2017;12(1):15-31.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
Authors: JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017;21(2):179-194.e4.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis-related genes
Authors: Y Hosokawa, T Toyoda, K Fukui, MY Baden, M Funato, Y Kondo, T Sudo, H Iwahashi, M Kishida, C Okada, A Watanabe, I Asaka, K Osafune, A Imagawa, I Shimomura
J Diabetes Investig, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells
Authors: C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat
J. Biol. Chem., 2017;0(0):.
Species: Sheep
Sample Type: Whole Cells
Application: Bioassay
Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate
Authors: AG Freire, A Waghray, F Soares-da-, TP Resende, DF Lee, CF Pereira, DS Nascimento, IR Lemischka, P Pinto-do-Ó
Stem Cell Reports, 2017;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation
Authors: M Ito, S Sun, T Fukuhara, R Suzuki, M Tamai, T Yamauchi, K Nakashima, YI Tagawa, S Okazaki, Y Matsuura, T Wakita, T Suzuki
Oncotarget, 2017;8(33):53899-53915.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes
Authors: N Merienne, G Vachey, L de Longpre, C Meunier, V Zimmer, G Perriard, M Canales, A Mathias, L Herrgott, T Beltramine, A Maulet, T Dequesne, C Pythoud, M Rey, L Pellerin, E Brouillet, AL Perrier, R du Pasquie, N Déglon
Cell Rep, 2017;20(12):2980-2991.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening
Authors: ZQ He, BL Xia, YK Wang, J Li, GH Feng, LL Zhang, YH Li, HF Wan, TD Li, K Xu, XW Yuan, YF Li, XX Zhang, Y Zhang, L Wang, W Li, Q Zhou
Cell Rep, 2017;20(9):2227-2237.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Activin signaling is an essential component of the TGF-? induced pro-metastatic phenotype in colorectal cancer
Authors: JJ Staudacher, J Bauer, A Jana, J Tian, T Carroll, G Mancinelli, Ö Özden, N Krett, G Guzman, D Kerr, P Grippo, B Jung
Sci Rep, 2017;7(1):5569.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis
Authors: NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry
Cell Rep, 2017;20(7):1597-1608.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes
Authors: G Yücel, Z Zhao, I El-Battraw, H Lan, S Lang, X Li, F Buljubasic, WH Zimmermann, L Cyganek, J Utikal, U Ravens, T Wieland, M Borggrefe, XB Zhou, I Akin
Sci Rep, 2017;7(1):2935.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
Sci Rep, 2017;7(1):2585.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols
Authors: D Jeziorowsk, V Fontaine, C Jouve, E Villard, S Dussaud, D Akbar, V Letang, P Cervello, JM Itier, MP Pruniaux, JS Hulot
Int J Mol Sci, 2017;18(6):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer
Authors: DD Seachrist, ST Sizemore, E Johnson, FW Abdul-Kari, KL Weber Bonk, RA Keri
Breast Cancer Res., 2017;19(1):66.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin Receptor Type IIA (ACVR2A) Functions Directly in Osteoblasts as a Negative Regulator of Bone Mass
Authors: BC Goh, V Singhal, AJ Herrera, RE Tomlinson, S Kim, MC Faugere, EL Germain-Le, TL Clemens, SJ Lee, DJ DiGirolamo
J. Biol. Chem., 2017;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
Authors: M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia, HJ Chen, M Witherspoo, M Gordillo, JZ Xiang, FR Maxfield, S Lipkin, T Evans, S Chen
Nat. Med., 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
Authors: NG Kooreman, PE de Almeida, JP Stack, RV Nelakanti, S Diecke, NY Shao, RJ Swijnenbur, V Sanchez-Fr, E Matsa, C Liu, AJ Connolly, JF Hamming, PHA Quax, MA Brehm, DL Greiner, LD Shultz, JC Wu
Cell Rep, 2017;20(8):1978-1990.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5
Authors: LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust
PLoS ONE, 2017;12(5):e0177188.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin A more prominently regulates muscle mass in primates than does GDF8
Authors: E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada
Nat Commun, 2017;8(0):15153.
Species: Human
Sample Type: Recombinant Protein
Application: Surface Plasmon Resonance
Direct comparison of distinct naive pluripotent states in human embryonic stem cells
Authors: S Warrier, M Van der Je, G Duggal, L Tilleman, E Sutherland, J Taelman, M Popovic, S Lierman, S Chuva De S, A Van Soom, L Peelman, F Van Nieuwe, DIM De Coninck, B Menten, P Mestdagh, J Van de Som, D Deforce, P De Sutter, B Heindryckx
Nat Commun, 2017;8(0):15055.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations
Authors: Q Gu, J Wang, L Wang, ZX Liu, WW Zhu, YQ Tan, WF Han, J Wu, CJ Feng, JH Fang, L Liu, L Wang, W Li, XY Zhao, BY Hu, J Hao, Q Zhou
Stem Cell Reports, 2017;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
Nat Commun, 2017;8(1):331.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
A pluripotent stem cell-based model for post-implantation human amniotic sac development
Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
Nat Commun, 2017;8(1):208.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Differentiation of cardiomyocytes and generation of human engineered heart tissue
Authors: K Breckwoldt, D Letuffe-Br, I Mannhardt, T Schulze, B Ulmer, T Werner, A Benzin, B Klampe, MC Reinsch, S Laufer, A Shibamiya, M Prondzynsk, G Mearini, D Schade, S Fuchs, C Neuber, E Krämer, U Saleem, ML Schulze, ML Rodriguez, T Eschenhage, A Hansen
Nat Protoc, 2017;12(6):1177-1197.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation
Nat Commun, 2016;7(0):12603.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Activin A programs the differentiation of human TFH cells
Nat Immunol, 2016;17(8):976-84.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Growth hormone is permissive for neoplastic colon growth
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Visualization of the Epiblast and Visceral Endodermal Cells Using Fgf5-P2A-Venus BAC Transgenic Mice and Epiblast Stem Cells
PLoS ONE, 2016;11(7):e0159246.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A strategy to ensure safety of stem cell-derived retinal pigment epithelium cells
Stem Cell Res Ther, 2016;7(1):127.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Heparin Promotes Cardiac Differentiation of Human Pluripotent Stem Cells in Chemically Defined Albumin-Free Medium, Enabling Consistent Manufacture of Cardiomyocytes
Stem Cells Transl Med, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling
Stem Cell Reports, 2016;7(5):884-896.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose
PLoS ONE, 2016;11(9):e0163580.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
Authors: N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
Nat. Med., 2016;22(12):1421-1427.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages
EMBO Mol Med, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Repressed SIRT1/PGC-1? pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
J Transl Med, 2016;14(1):344.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
In�Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts
Authors: S Kadota, L Pabon, H Reinecke, CE Murry
Stem Cell Reports, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling
Authors: L Song, J Chen, G Peng, K Tang, N Jing
J. Biol. Chem., 2016;291(29):15212-25.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling
Stem Cell Res Ther, 2016;7(1):115.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Transplantation of Donor-Origin Mouse Embryonic Stem Cell-Derived Thymic Epithelial Progenitors Prevents the Development of Chronic Graft-Versus-Host Disease in Mice
Stem Cells Transl Med, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
PLoS ONE, 2015;10(3):e0119904.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells.
Authors: Nagaoka M, Kobayashi M, Kawai C, Mallanna S, Duncan S
PLoS ONE, 2015;10(8):e0136350.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts.
Authors: Gerbin K, Yang X, Murry C, Coulombe K
PLoS ONE, 2015;10(7):e0131446.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells.
Authors: Yang W, Liu Y, Slovik K, Wu J, Duncan S, Rader D, Morrisey E
PLoS ONE, 2015;10(8):e0134995.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.
Authors: Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, Wang C
PLoS ONE, 2015;10(6):e0129643.
Species: Mouse
Sample Type: Whole Tissue
Application: Bioassay
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.
Authors: Latres E, Pangilinan J, Miloscio L, Bauerlein R, Na E, Potocky T, Huang Y, Eckersdorff M, Rafique A, Mastaitis J, Lin C, Murphy A, Yancopoulos G, Gromada J, Stitt T
Skelet Muscle, 2015;5(0):34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay

Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16).

参考图片

Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC) induces hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 is 0.2‑1.2 ng/mL.

1 μg/lane of Recombinant Human/Mouse/Rat Activin A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 14 kDa and 24 kDa, respectively.

BG01V human embryonic stem cells were differentiated into endoderm using media supplemented with Recombinant Human/Mouse/Rat Activin A (Catalog # 338-AC). Control cells were cultured in medium without recombinant Activin A. Differentiation into endoderm was confirmed by positive-staining for Claudin-6 (red) and Sox17 (green) using the Mouse Anti-Human Claudin-6 Monoclonal Antibody (Catalog # MAB3656) and the Goat Anti-Human Sox17 Polyclonal Antibody (Catalog # AF1924), respectively. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.

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