货号： 130-097-286 品牌： Miltenyi
PepTivator PRAME, human - RG
PepTivator ® PRAME is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the preferentially expressed antigen of melanoma (PRAME) (UniProt ID: P78395). In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.
PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through certain retinoic acid receptors. Moreover, it is a melanoma antigen aberrantly expressed in chronic lymphocytic leukemia and mantle cell lymphoma.